Description
Cautions and Contraindications:
Pregnancy. Nursing.
EGCG blocked bortezomib’s antitumor effects at levels that are commonly achieved with the use of available concentrated green tea supplements (as low as 2.5 μM – which can be attained with two to three 250 mg capsules of green tea extract) suggesting the impact is very real for patients supplementing their therapy. Bortezomib is a proteasome inhibitor. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma.
Prolonged green tea extract (GTE) supplementation dramatically increased hepatic oxidative stress, inflammation and liver injury, and altered the bile acid synthesis pathway in mice fed a high cholesterol diet (HCD).
